| Date | Status | Player | Injury | Target Return? | Prognosis |
|---|
| 2025-04-19 | Played | Brandon Nimmo | Knee inflammation | 2025-04-18 | Brandon Nimmo played in the game on 2025-04-18 |
| 2025-04-19 | Played | Brice Turang | Shoulder soreness | 2025-04-18 | Brice Turang played in the game on 2025-04-18 |
| 2025-04-19 | Played | Connor Norby | Strained oblique | 2025-04-19 | Connor Norby played in the game on 2025-04-19 |
| 2025-04-18 | 15-Day IL | Justin Steele | Elbow surgery | 2025-11-01 | Out for 2025 season |
| 2025-04-18 | Played | Nolan Gorman | Strained hamstring | 2025-04-17 | Nolan Gorman played in the game on 2025-04-17 |
| 2025-04-17 | 15-Day IL | A.J. Puk | Elbow inflammation | | No timetable for return |
| 2025-04-16 | 10-Day IL | Christian Encarnacion-Strand | Lower back inflammation | 2025-04-29 | No timetable for return |
| 2025-04-16 | 10-Day IL | Derek Hill | Sprained wrist | 2025-04-29 | No timetable for return |
| 2025-04-16 | 60-Day IL | DJ Herz | Tommy John surgery | 2025-11-01 | Out for 2025 season |
| 2025-04-15 | 10-Day IL | Paul DeJong | Fractured nose | 2025-04-29 | No timetable for return |
| 2025-04-14 | 10-Day IL | Endy Rodríguez | Finger laceration (right index) | 2025-04-29 | No timetable for return |
| 2025-04-14 | 15-Day IL | Eli Morgan | Elbow impingement | 2025-05-04 | No timetable for return |
| 2025-04-14 | 60-Day IL | Jordan Montgomery | Tommy John surgery | 2025-11-01 | Out for 2025 season |
| 2025-04-13 | 10-Day IL | Brandon Lockridge | Strained hamstring | 2025-04-29 | No timetable for return |
| 2025-04-12 | 10-Day IL | Jose Siri | Fractured shin | 2025-04-29 | No timetable for return |
| 2025-04-12 | 10-Day IL | Tyler Freeman | Strained oblique | 2025-04-29 | No timetable for return |
| 2025-04-12 | 10-Day IL | Kris Bryant | Lumbar degenerative disc disease | 2025-04-29 | Expected to return when eligible or soon thereafte |
| 2025-04-11 | 10-Day IL | Masyn Winn | Back spasms | 2025-04-29 | Rehab assignment (4/18) |
| 2025-04-11 | 10-Day IL | CJ Abrams | Strained hip flexor | 2025-04-29 | No timetable for return |
| 2025-04-09 | 10-Day IL | Nick Fortes | Strained oblique | 2025-04-29 | No timetable for return |
| 2025-04-08 | 15-Day IL | Orlando Ribalta | Strained biceps | 2025-05-04 | No timetable for return |
| 2025-04-08 | 60-Day IL | Reynaldo López | Arthroscopic shoulder surgery | 2025-07-01 | Shut down for at least 12 weeks |
| 2025-04-06 | 10-Day IL | Iván Herrera | Knee inflammation (bone bruise) | 2025-05-04 | Expected to miss at least 4 weeks |
| 2025-04-06 | 10-Day IL | Jake Cronenworth | Fractured rib (non-displaced) | 2025-04-29 | No timetable for return |
| 2025-04-06 | 10-Day IL | Jared Triolo | Strained back (lumbar) | 2025-04-18 | Rehab assignment (4/15) |
| 2025-04-06 | 10-Day IL | Jackson Merrill | Strained hamstring | 2025-04-29 | No timetable for return |
| 2025-04-06 | 15-Day IL | Sam Moll | Shoulder impingement | 2025-05-04 | No timetable for return |
| 2025-04-05 | 15-Day IL | Colin Holderman | Sprained knee | 2025-05-04 | No timetable for return |
| 2025-04-05 | 15-Day IL | Connor Thomas | Elbow arthritis | 2025-05-04 | No timetable for return |
| 2025-04-04 | 10-Day IL | Ketel Marte | Strained hamstring | 2025-04-29 | No timetable for return |
| 2025-04-03 | 15-Day IL | Nestor Cortes | Strained elbow flexor | 2025-05-04 | No timetable for return |
| 2025-04-02 | 15-Day IL | Blake Snell | Shoulder inflammation | 2025-05-04 | No timetable for return |
| 2025-03-31 | 15-Day IL | Michael Soroka | Strained biceps | 2025-05-04 | No timetable for return |
| 2025-03-30 | 15-Day IL | Aaron Civale | Strained hamstring | 2025-05-04 | No timetable for return |
| 2025-03-29 | 10-Day IL | Jerar Encarnacion | Hand surgery (left) | 2025-05-24 | Expected to miss at least 8 weeks |
| 2025-03-27 | 10-Day IL | Nick Gonzales | Fractured ankle (non-displaced) | 2025-04-29 | No timetable for return |
| 2025-03-24 | 15-Day IL | Ryan Brasier | Hip discomfort | 2025-05-04 | No timetable for return |
| 2025-03-22 | 15-Day IL | Tyson Miller | Hip impingement | 2025-05-04 | No timetable for return |
| 2025-03-20 | 10-Day IL | Thairo Estrada | Fractured wrist (right) | 2025-05-01 | Out 4-8 weeks |
| 2025-03-20 | 15-Day IL | Kevin Ginkel | Shoulder inflammation | 2025-05-04 | No timetable for return |
| 2025-03-18 | 15-Day IL | Declan Cronin | Strained hip | 2025-05-04 | Rehab assignment (4/10) |
| 2025-03-17 | 15-Day IL | Ryan Weathers | Strained forearm | 2025-04-21 | Expected to miss at least 4-6 weeks |
| 2025-03-17 | 15-Day IL | Paul Blackburn | Knee inflammation | 2025-05-04 | Shut down for 7-10 days |
| 2025-03-16 | 15-Day IL | Ranger Suárez | Back tightness | 2025-05-04 | Rehab assignment (4/10) |
| 2025-03-16 | 60-Day IL | Jared Jones | Elbow discomfort | 2025-04-27 | Shut down for at least 6 weeks |
| 2025-03-15 | 15-Day IL | Tobias Myers | Strained oblique | 2025-05-04 | Rehab assignment (4/8) |
| 2025-03-14 | 10-Day IL | Nacho Alvarez Jr. | Wrist inflammation | 2025-04-29 | No timetable for return |
| 2025-03-14 | 15-Day IL | Derek Law | Forearm inflammation | 2025-05-04 | No timetable for return |
| 2025-03-14 | 60-Day IL | Jeff Criswell | Tommy John surgery | 2025-11-01 | Out for 2025 season |
| 2025-03-14 | 60-Day IL | Michael Grove | Shoulder surgery | 2025-11-01 | Out for 2025 season |
| 2025-03-14 | 60-Day IL | Matt Waldron | Strained oblique | 2025-06-18 | No timetable for return |
| 2025-03-14 | 60-Day IL | Blake Walston | Tommy John surgery | 2025-11-01 | Out for 2025 season |
| 2025-03-13 | 10-Day IL | Andrés Chaparro | Strained oblique | 2025-04-29 | No timetable for return |
| 2025-03-13 | 15-Day IL | Yu Darvish | Elbow inflammation | 2025-05-04 | No timetable for return |
| 2025-03-12 | 10-Day IL | Tyler Stephenson | Strained oblique | 2025-04-29 | No timetable for return |
| 2025-03-10 | 10-Day IL | Jeff McNeil | Strained oblique | 2025-04-29 | Rehab assignment (4/11) |
| 2025-03-10 | 10-Day IL | Francisco Alvarez | Hamate surgery (left hand) | 2025-04-29 | Rehab assignment (4/9) |
| 2025-03-05 | 60-Day IL | Andrew Nardi | Back tightness | 2025-06-18 | No timetable for return |
| 2025-03-04 | 60-Day IL | Jhony Brito | Strained forearm | 2025-06-18 | No timetable for return |
| 2025-03-03 | 15-Day IL | Aaron Ashby | Strained oblique | 2025-05-04 | No timetable for return |
| 2025-03-02 | 15-Day IL | Austin Gomber | Shoulder soreness | 2025-05-04 | Rehab assignment (4/6) |
| 2025-03-01 | 15-Day IL | Kendall Graveman | Strained back (lumbar) | 2025-05-04 | No timetable for return |
| 2025-03-01 | 60-Day IL | Edgardo Henriquez | Foot discomfort | 2025-06-18 | No timetable for return |
| 2025-02-28 | 10-Day IL | Blaze Alexander | Strained oblique | 2025-04-29 | Rehab assignment (4/8) |
| 2025-02-25 | 15-Day IL | Zach Brzykcy | Strained quad | 2025-05-04 | Rehab assignment (4/15) |
| 2025-02-24 | 60-Day IL | Zack Thompson | Strained lat | 2025-06-18 | No timetable for return |
| 2025-02-23 | 60-Day IL | Nick Madrigal | Fractured shoulder (non-throwing) | 2025-06-18 | Questionable for 2025 season |
| 2025-02-22 | 10-Day IL | Blake Perkins | Fractured shin | 2025-05-01 | Out thru at least April |
| 2025-02-22 | 10-Day IL | Weston Wilson | Strained oblique | 2025-04-29 | Rehab assignment (4/8) |
| 2025-02-22 | 15-Day IL | Sean Manaea | Strained oblique | 2025-05-04 | Shut down thru at least mid-April |
| 2025-02-14 | 15-Day IL | Bryan Hoeing | Strained shoulder | 2025-05-04 | No timetable for return |
| 2025-02-14 | 15-Day IL | Sean Reynolds | Stress reaction in foot | 2025-05-04 | No timetable for return |
| 2025-02-14 | 15-Day IL | Javier Assad | Strained oblique | 2025-05-04 | Rehab assignment (4/15) |
| 2025-02-14 | 60-Day IL | DL Hall | Strained lat | 2025-06-18 | No timetable for return |
| 2025-02-12 | 15-Day IL | Frankie Montas | Strained lat | 2025-04-02 | Shut down for 6-8 weeks |
| 2025-02-12 | 60-Day IL | Tom Murphy | Mid-back disc herniation | 2025-06-18 | No timetable for return |
| 2025-02-07 | 10-Day IL | Spencer Horwitz | Thumb surgery | 2025-03-28 | Out 6-8 weeks |
| 2025-01-14 | 15-Day IL | Rhett Lowder | Strained forearm | 2025-05-04 | No timetable for return |
| 2024-12-16 | 60-Day IL | Braxton Garrett | UCL revision surgery (internal brace) | 2025-11-01 | Out for 2025 season |
| 2024-11-14 | 15-Day IL | Evan Phillips | PRP injection in shoulder (torn rotator cuff) | 2025-05-04 | Rehab assignment (4/3) |
| 2024-11-14 | 15-Day IL | Michael Kopech | Forearm inflammation | 2025-05-04 | No timetable for return |
| 2024-11-14 | 60-Day IL | Brusdar Graterol | Shoulder surgery (labrum) | 2025-07-01 | Out thru at least June |
| 2024-11-06 | 60-Day IL | Clayton Kershaw | Toe surgery / Knee surgery | 2025-06-18 | Rehab assignment (4/16) |
| 2024-10-29 | 60-Day IL | Joe Jiménez | Knee surgery (cartilage repair) | 2025-08-01 | Out thru at least July |
| 2024-10-11 | 60-Day IL | Julian Aguiar | Tommy John surgery | 2025-11-01 | Out for 2025 season |
| 2024-10-11 | 60-Day IL | Joe Musgrove | Tommy John surgery | 2025-11-01 | Out for 2025 season |
| 2024-10-09 | 60-Day IL | Gavin Stone | Shoulder surgery | 2025-11-01 | Out for 2025 season |
| 2024-09-25 | 60-Day IL | Christian Scott | Tommy John surgery (internal brace) | 2025-11-01 | Out for 2025 season |
| 2024-09-14 | 60-Day IL | Brandon Williamson | Tommy John surgery | 2025-11-01 | Out for 2025 season |
| 2024-08-25 | 60-Day IL | River Ryan | Tommy John surgery | 2025-11-01 | Out for 2025 season |
| 2024-07-30 | 60-Day IL | Kyle Hurt | Tommy John surgery | 2025-06-18 | Questionable for 2025 season |
| 2024-07-24 | 60-Day IL | Josiah Gray | Tommy John surgery (internal brace) | 2025-06-18 | No timetable for return |
| 2024-07-12 | 60-Day IL | Drew Smith | Tommy John surgery (internal brace) | 2025-06-18 | No timetable for return |
| 2024-06-24 | 60-Day IL | Robert Gasser | Tommy John surgery | 2025-06-18 | No timetable for return |
| 2024-06-05 | 10-Day IL | Ronald Acuña Jr. | Knee surgery (torn ACL) | 2025-05-01 | Out thru at least April |
| 2024-05-16 | 60-Day IL | Emmet Sheehan | Tommy John surgery | 2025-06-18 | No timetable for return |
| 2024-04-08 | 60-Day IL | Eury Pérez | Tommy John surgery | 2025-06-18 | Expected to begin a rehab assignment in mid-May |
| 2024-03-21 | 60-Day IL | Dauri Moreta | Tommy John surgery | 2025-06-18 | No timetable for return |
| 2024-03-01 | 60-Day IL | Mason Thompson | Tommy John surgery | 2025-06-18 | No timetable for return |
| 2024-01-02 | 10-Day IL | Ronny Mauricio | Knee surgery (torn ACL) | 2025-04-29 | No timetable for return |
| 2023-12-06 | 60-Day IL | Johan Oviedo | Tommy John surgery | 2025-06-18 | No timetable for return |
| 2023-10-13 | 15-Day IL | Brandon Woodruff | Shoulder surgery (anterior capsule repair) | 2025-05-04 | Rehab assignment (4/12) |
| 2023-09-01 | 15-Day IL | Tony Gonsolin | Tommy John surgery | 2025-05-04 | Rehab assignment (4/3) |
| 2023-03-22 | 15-Day IL | Cade Cavalli | Tommy John surgery | 2025-05-04 | Rehab assignment (4/19) |